The textile industry continues to find more sustainable options for dyeing in their endeavor to address the water usage and more visible environmental impacts associated with the dyeing processes. Supercritical carbon dioxide (scCO\(_2\)) has emerged as an excellent solvent-free catalyst for synthetic materials and natural fibers particularly friendly with regards to waste generation and color build-up but very few studies have been published on the dyeing of blended fabrics, such as polyester-cotton, nylon-wool f etc that are industrially highly used in this review we shall be dealing with the dyeing conditions for the above mixtures of reactive disperse dyes within the scCO\(_2\) range, especially the dyes of vinyl sulfone and dichlorotriazine. Using the response surface method (RSM), a range of pressures 200–300 bar, temperatures between 100–120\(^\circ\)C, and relative humidity for scCO\(_2\) from 0–97%.RH), we were able to map the effects of adsorption, color depth and setting on each fibre in the blend. The conclusions are that the optimum reaction conditions for the fibre fragments depend on variable chemical recognition for drug molecules and its interaction with scCO\(_2\) while absorption of dye fixation by polyester was independent of scCO\(_2\) water, but, cotton treated at more water values seems to enhance absorption. Nylon responds well under high pressure conditions, and leather improves with storage under increased temperature and moisture. Optimization of parameters to attain uniform color in each blend of fibers was identified by the analysis using the RSM. It thus means that pressure, temperature, and humidity can be regulated to achieve and fine-tune desired color depth without damaging this sustainable environment.